K9 Advantix II, Large Dog 21–55 lb (4 doses) vs Advantage II, Large Dog 21–55 lb (6 doses)
Side by side on specifications and purchase options, so you can judge which suits your dog.
Affiliate disclosure: As an Amazon Associate, PawBench earns from qualifying purchases. Prices shown are approximate and subject to change. Always verify current pricing on Amazon before purchasing.

K9 Advantix II, Large Dog 21–55 lb (4 doses)
$57.42 · ★ 4.4 (44,707)
vs

Advantage II, Large Dog 21–55 lb (6 doses)
$66.97 · ★ 4.5 (4,696)
73
Effectiveness
75
76
Ingredients
78
76
Vet Endorsement
72
76
Value
77
71
Owner Satisfaction
74
Differences only
| Spec | ||
|---|---|---|
| Buy | ||
PawBench Scoremethodology → | Effectiveness 73 Ingredients 76 Vet Endorsement 76 Value 76 Owner Satisfaction 71 | Effectiveness 75 Ingredients 78 Vet Endorsement 72 Value 77 Owner Satisfaction 74 |
| Doses | 4 (monthly) | 6 (monthly) |
| Dog Size | 21–55 lb | 21–55 lb |
| Active Ingredients | Imidacloprid, permethrin, pyriproxyfen | Imidacloprid, pyriproxyfen |
| Regulation | EPA-registered pesticide | EPA-registered pesticide |
| Cat Safety | Do not use on cats | — |
| Ticks | — | Not covered |
* Prices are approximate and may vary. Please check the latest price on Amazon.
Pros & cons
K9 Advantix II, Large Dog 21–55 lb (4 doses)
Pros
- ✓EPA-registered topical that kills and repels fleas, ticks and mosquitoes, per the label
- ✓Also covers biting flies and lice, per the label
- ✓Waterproof once dry; no prescription needed
Cons
- ✗Toxic to cats: never use on a cat, and keep treated dogs away from cats until the dose is dry
- ✗Monthly application; it can leave a greasy spot for a day
Advantage II, Large Dog 21–55 lb (6 doses)
Pros
- ✓EPA-registered topical that kills adult fleas, larvae and eggs, per the label
- ✓Six monthly doses in one pack
- ✓Fragrance-free and waterproof after 24 hours, per the maker
Cons
- ✗Fleas and lice only: it does not kill ticks
- ✗Monthly application

