Virbac Epi-Otic Advanced Ear Cleaner vs Zymox Otic Enzymatic Solution with 1% Hydrocortisone

Head-to-head comparison — specs, scores, pros & cons, and our expert verdict to help you pick the right one for your dog.

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Our Pick
Virbac Epi-Otic Advanced Ear Cleaner — product shown in side-by-side comparison on PawBench
VirbacPremium

Virbac Epi-Otic Advanced Ear Cleaner

4.7(9,343 reviews)
9.1/10 overall

From $23.99(prices may vary)

📦 Buy on Amazon
Zymox Otic Enzymatic Solution with 1% Hydrocortisone — product shown in side-by-side comparison on PawBench
ZymoxPremium

Zymox Otic Enzymatic Solution with 1% Hydrocortisone

4.7(77,633 reviews)
8.9/10 overall

From $26.99(prices may vary)

📦 Buy on Amazon

Ratings Breakdown

CategoryVirbac Epi-Otic Advanced Ear CleanerZymox Otic Enzymatic Solution with 1% Hydrocortisone
Overall
9.1
8.9
Value
8.2
8
Quality
Durability
Ease of Use

Pros & Cons

Virbac Epi-Otic Advanced Ear Cleaner

Pros

  • pH-balanced, alcohol-free — won't sting inflamed canals
  • Mild antimicrobial action via salicylic acid and chlorhexidine derivatives
  • Vet-office benchmark — the cleaner Virbac sells to clinics worldwide
  • Anti-adhesive technology reduces bacterial biofilm in the canal

Cons

  • Pricier than drugstore alternatives
  • Not enzymatic — chronic recurrent otitis may need Zymox instead

Zymox Otic Enzymatic Solution with 1% Hydrocortisone

Pros

  • Enzymatic action (lactoperoxidase, lactoferrin, lysozyme) — handles biofilm mechanical cleaners can't
  • Backed by published veterinary dermatology literature for chronic otitis
  • 1% hydrocortisone reduces inflammation and scratching
  • OTC alternative to vet-prescribed topical antibiotics for many uncomplicated cases

Cons

  • Do not clean the ear before use — the enzymes need cerumen to work on
  • Not for ruptured eardrums; vet exam first if there's discharge or head tilt

Specs Comparison

SpecVirbac Epi-Otic Advanced Ear CleanerZymox Otic Enzymatic Solution with 1% Hydrocortisone
Active IngredientSalicylic acid, EDTA, chlorhexidine derivativesLP3 enzyme system + 1% hydrocortisone
Volume8 oz bottle1.25 oz bottle
ApplicationFill canal, massage base of ear 20s, let shake, wipe outer earFill canal once daily, do not pre-clean; 7–14 day course
pHBalanced (acidic, near 5.5)Balanced for enzymatic activity
Spec
Buy
PawBench Scoremethodology →
Quality
76
Ease of Use
76
Versatility
76
Value
65
Owner Satisfaction
91
Quality
76
Ease of Use
76
Versatility
76
Value
65
Owner Satisfaction
93
Buyer sentiment
Effectiveness Ear Cleaning Quality Scent

Buyers praise effectiveness, ear cleaning, quality and scent.

Based on 2,856 user mentions

Effectiveness Ear Relief Value for money Itching Relief

Buyers praise effectiveness, ear relief, value for money and itching relief.

Based on 20,421 user mentions

Active IngredientSalicylic acid, EDTA, chlorhexidine derivativesLP3 enzyme system + 1% hydrocortisone
Volume8 oz bottle1.25 oz bottle
ApplicationFill canal, massage base of ear 20s, let shake, wipe outer earFill canal once daily, do not pre-clean; 7–14 day course
pHBalanced (acidic, near 5.5)Balanced for enzymatic activity

* Prices are approximate and may vary. Please check the latest price on Amazon.

🏆

Our Verdict

Virbac Epi-Otic Advanced Ear Cleaner

Winner

Virbac Epi-Otic Advanced Ear Cleaner

9.1/10 overall

It's extremely close, but Virbac Epi-Otic Advanced Ear Cleaner edges ahead with a slightly higher overall score (9.1 vs 8.9). Both are excellent choices — you really can't go wrong with either. Pick the one that best fits your dog's specific needs and your budget.

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